Role of the Medial Limbic System in the Memory Process: A Hypothesis Based on a Radioactive 2-Deoxyglucose Study

  • Ken’ichi Matsunami
  • Takashi Kawashima
  • Hirotaka Satake
  • Masataka Suzuki
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Alzheimer or Parkinson patients suffer from some memory deficits in the later course of their illness. It is also reported that MPTP-treated monkeys showed cognitive disturbances without Parkinsonian motor deficits.1 Therefore, it would be very helpful to determine the activity of memory-related structures in the normal brain for the development of more appropriate therapeutic or clinical treatments. In the present study, the 2-deoxy-d-glucose (2-DG) method2 was employed to reveal active sites in the brain while the monkey was performing a delayed response. This paradigm is known to test for short-term memory. The results have been already published in final form.3,4


Target Zone Retrosplenial Cortex Motor Memory Anterior Nucleus Local Cerebral Glucose Utilization 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Ken’ichi Matsunami
    • 1
  • Takashi Kawashima
    • 1
  • Hirotaka Satake
    • 1
  • Masataka Suzuki
    • 2
  1. 1.Dept. of Neurophysiol., Inst. of Equilibrium Res.Gifu Univ. School of MedicineGifu CityJapan
  2. 2.Dept. of SportKinjyo Univ.Ohmori Moriyama-ku, Nagoya CityJapan

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