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Screening for Psychotherapeutic Chemicals by Analysis of Conscious Activity in the Mouse

  • Akifumi Higashi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The notions and methods discussed below will at least allow the screening of new types of drugs. New types of drugs in the screening stage will not only improve the synaptic mechanism for excitation and inhibition, as conventional drugs do, but will also improve the performance of the operating system of the brain. This suggests the existence of chemical compounds that cannot be inferred through limited (localized), sharp and realistic experimental analysis of biochemistry and neurophysiology, since the variables for the integration of varid phenomena in the brain must also be analyzed.

Keywords

Sleep Stage Activity Vector Atropine Sulfate Cumulative Curve Wakefulness State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    K. R. Popper and J. C. Eccles,“The self and its brain”, Springer International (1985).Google Scholar
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    F. Crick and G. Mitchison, The function of dream sleep, Nature 304: 111 (1983).PubMedCrossRefGoogle Scholar
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    A. Higashi, Brain’s calculating principle, in: “Alzheimer’s and Parkinson’s Diseases 2: Basic and Therapeutic Strategies”, T, Nagatsu, A. Fisher, and M. Yoshida, eds., Plenum Publishing Corp. (1990).Google Scholar
  4. 4.
    A. Higashi, Method of dynamic behavioral stage analysis (DBSAM) in the free moving mouse, Physiol. Behay. 38: 525 (1986).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Akifumi Higashi
    • 1
  1. 1.National Institute for Physiological SciencesOkazaki, 444Japan

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