Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody
Nerve growth factor (NGF) is a protein of known importance for the development and maintenance of peripheral sympathetic neurons (Levi-Montalcini and Angeletti, 1968; Yu et al., 1978). Recent anatomical, behavioral, and biochemical studies have been interpreted as suggesting a possible role for NGF in the central nervous system (Honegger and Lenoir, 1982; Gnahn et al., 1983; Fischer et al .; 1987). However, no direct evidence exists implicating altered levels of NGF as causative in either normal aging or in accelerating neuro-degenerative processes such as Alzheimer’s disease. Furthermore, intra-ventricular and intracortical injection of anti-NGF-antibody failed to produce anadverse effect on forebrain cholinergic neurons (Gnahn et al.,1983). It is so far not known whether a deficiency of NGF is responsible for impairments in learning and memory. We report here that continuous intracerebral infusion of a specific Fab’ fragment of antiserum to NGF (anti-NGF) over a period of four weeks impairs learning and memory retention of the water maze and habituation tasks in rats.
KeywordsNerve Growth Factor Cholinergic Neuron Nerve Growth Factor Level Movement Count Goal Latency
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