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Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody

  • Toshitaka Nabeshima
  • Shin-ichi Ogawa
  • Hidenao Nishimura
  • Kiyofumi Yamada
  • Kazuyuki Fuji
  • Tsutomu Kameyama
  • Rie Takeuchi
  • Kyozo Hayashi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Nerve growth factor (NGF) is a protein of known importance for the development and maintenance of peripheral sympathetic neurons (Levi-Montalcini and Angeletti, 1968; Yu et al., 1978). Recent anatomical, behavioral, and biochemical studies have been interpreted as suggesting a possible role for NGF in the central nervous system (Honegger and Lenoir, 1982; Gnahn et al., 1983; Fischer et al .; 1987). However, no direct evidence exists implicating altered levels of NGF as causative in either normal aging or in accelerating neuro-degenerative processes such as Alzheimer’s disease. Furthermore, intra-ventricular and intracortical injection of anti-NGF-antibody failed to produce anadverse effect on forebrain cholinergic neurons (Gnahn et al.,1983). It is so far not known whether a deficiency of NGF is responsible for impairments in learning and memory. We report here that continuous intracerebral infusion of a specific Fab’ fragment of antiserum to NGF (anti-NGF) over a period of four weeks impairs learning and memory retention of the water maze and habituation tasks in rats.

Keywords

Nerve Growth Factor Cholinergic Neuron Nerve Growth Factor Level Movement Count Goal Latency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Toshitaka Nabeshima
    • 1
  • Shin-ichi Ogawa
    • 1
  • Hidenao Nishimura
    • 1
  • Kiyofumi Yamada
    • 1
  • Kazuyuki Fuji
    • 1
  • Tsutomu Kameyama
    • 1
  • Rie Takeuchi
    • 2
  • Kyozo Hayashi
    • 2
  1. 1.Department of Chemical Pharmacology, Faculty of Pharmaceutical SciencesMeijo UniversityNagoyaJapan
  2. 2.Department of PharmaceuticsGifu Pharmaceutical UniversityGifuJapan

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