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Interleukin-3 Promotes Neurite Outgrowth and Elevates Choline Acetyltransferase Activity

  • Masahiro Kamegai
  • Tatsuhide Kunishita
  • Masatoyo Nishizawa
  • Takeshi Tabira
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Alzheimer’s disease (AD) is associated with the degeneration of cholinergic neurons in the hippocampus and basal forebrain. Since nerve growth factor (NGF) was found to enhance choline acetyltransferase (ChAT) activity, and the infusion of NGF into the rat cerebral ventricle prevented death of lesioned septal cholinergic neurons and improved cognitive functions in old animals, NGF has been proposed as a therapeutic agent for AD. As basic fibroblast growth factor has a similar effect in vivo, we looked for other trophic factors for central cholinergic neurons. In this study we demonstrate that interleukin-3 (IL-3), which plays a role in the growth and differentiation of hematopoietic lineage cells, also acts as a novel trophic factor for central cholinergic neurons in primary cultures of mouse septal neurons and in cholinergic hybridoma line cell SN6.10.2.2.

Keywords

Nerve Growth Factor Glial Fibrillary Acidic Protein Cholinergic Neuron Trophic Factor ChAT Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Masahiro Kamegai
    • 1
  • Tatsuhide Kunishita
    • 1
  • Masatoyo Nishizawa
    • 1
  • Takeshi Tabira
    • 1
  1. 1.Division of Demyelinating Disease and AgingNational Institute of Neuroscience, NCNPKodaira, Tokyo 187Japan

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