Changes in Basal Forebrain Cholinergic Systems Following Excitotoxic Cell Death in the Hippocampus and Cerebral Neocortex
Many areas of the brain that exhibit neurodegenerative changes in Alzheimer-type dementias (DAT) appear to be interconnected via neuronal projections. The severity of pathology in the neocortex correlates statistically with known patterns of intracortical connections (Pearson et al., 1985), and the major affected subcortical regions, such as the nucleus basalis, locus coeruleus and dorsal raphe project prominently to the allo- or neocortex (Saper et al., 1987). Observations such as these have led to suggestions that the degeneration in some regions of the brain might be secondary to loss of neurons in other areas, resulting from a loss of target-derived trophic support (Appel, 1981; Hefti, 1983). The evidence that this might be the case is particularly suggestive for cholinergic neurons of the basal forebrain.
KeywordsNerve Growth Factor Cholinergic Neuron Basal Forebrain Medial Septum Nerve Growth Factor Receptor
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