Abstract
Alzheimer’s disease (AD) is characterised by a loss of memory and confusion. Neuropathological changes indicate neuronal loss and degeneration in the neocortex and the cholinergic basal forebrain. The cholinergic system is involved in some aspects of learning and memory and it has been suggested that some of the memory defects observed in AD are caused by this degeneration.
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Allen, S.J., Dawbarn, D., Spillantini, M.G., Goedert, M., Wilcock, G.K., Moss, T.H., and Semenenko, F.M., 1989, The distribution of β-nerve growth factor receptors in the human basal forebrain, J. Comp. Neurol., in press.
Dawbarn, D., Allen, S.J., and Semenenko, F.M., 1988a, Immunohistochemical localization of ß-nerve growth factor receptors in the forebrain of the rat, Brain Res., 440: 185.
Dawbarn, D., Allen, S.J., and Semenenko, F.M., 1988b, Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain. Neurosci. Letts., 94: 138.
Fischer, W., Wictorin, K., Bjorklund, A., Williams, L.R., Varon, S., and Gage, F.H., 1987, Amelioration of cholinergic neuronal atrophy and spatial memory impairment in aged rats by nerve growth factor, Nature, 329: 65.
Fonnum, F., 1975, A radiochemical method for the determination of choline acetyltransferase activity, J.Neurochem., 24: 407.
Gomez-Pinilla, F., Cotman, C., and Nieto-Sampedro, M., 1987, NGF receptor immunoreactivity in rat brain: topographic distribution and response to entorhinal ablation, Neurosci. Lett., 82: 260.
Hefti, F., Hartikka, J., Eckenstein, F., Gnahn, H., Heumann, R., and Schwab, M., 1985, Nerve growth factor (NGF) increases choline acetyltransferase but not survival or fiber growth of cultured septal cholinergic neurons, Neuroscience, 14: 55.
Hefti, F., Hartikka, J., Salvatierra, A., Weiner, W.J., and Mash, D.C., 1986, Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain, Neurosci. Lett., 69: 17.
Mobley, W.C., Rutkowski, J.L., Tennekoon, G.I., Gemski, J., Buchanan, K. and Johnston, M.V., 1986, Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons, Mol. Brain Res., 1: 53.
Raivich, G., and Kreutzberg, G.W., 1987, The localization and distribution of high affinity β-nerve growth factor binding sites in the central nervous system of the adult rat. A light microscopic autoradiographic study using [125] β-nerve growth factor, Neuroscience, 20: 23.
Richardson, P.M., Verge Issa, V.M.K., and Riopelle, R.J., 1986, Distribution of neuronal receptors for nerve growth factor in the rat, J. Neuroscience, 6: 2312.
Seiler, M., and Schwab, M.E., 1984, Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat, Brain Res., 300: 33.
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© 1990 Plenum Press, New York
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Dawbarn, D., Allen, S.J., Treanor, J.J.S., MacGowan, S.H., Wilcock, G.K. (1990). Distribution of NGF Receptors in Control and Alzheimer’s Disease Basal Forebrain. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_130
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_130
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