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Identification of Putative Amyloid A4-Splitting Enzymes with Two Endopeptidases Widely Distributed in Mammalian Cells

  • Shoichi Ishiura
  • Toshifumi Tsukahara
  • Takeshi Tabira
  • Koichi Suzuki
  • Hideo Sugita
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Alzheimer’s disease (AD) is characterized by the deposition of amyloid in the brain, especially in senile plaques and neurofibrillary tangles. Amyloid is thought to arise by abnormal cleavage of various proteins into self-aggregating fragments. The major component of AD amyloid is a 4.2-kD polypeptide referred to as the A4 or β-protein, and it corresponds to a membrane-spanning domain of a putative amyloid precursor protein (APP). A4 at positions 597 to 638 of the initially identified APP695 is hydrophobic and the C-terminal half of the A4 is buried in the membrane. The major peptide species in the amyloid plaque core in AD are peptide A4′, which corresponds to Phe600 to Ala638, and an A4 peptide.

Keywords

Neurofibrillary Tangle Prolyl Endopeptidase Abnormal Cleavage Multicatalytic Proteinase Porcine Skeletal Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shoichi Ishiura
    • 1
  • Toshifumi Tsukahara
    • 1
  • Takeshi Tabira
    • 1
  • Koichi Suzuki
    • 2
  • Hideo Sugita
    • 1
  1. 1.National Institute of NeuroscienceNCNPKodaira, TokyoJapan
  2. 2.Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

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