Interleukin-6 as a Neurotrophic Factor for Promoting Survival of Septal Cholinergic Neurons and Mesencephalic Catecholaminergic Neurons from Postnatal Rats
Neuronal differentiation and survival are supported by several kinds of neurotrophic factors in the central nervous system (CNS) as in the peripheral nervous system (PNS). The well-known nerve frowth factor (NGF), target derived growth factor, is synthesized1–4 and acts on cholinergic neurons5–12 in the CNS; however the action of NGF on other neurons is limited. We have been studying such factors that act on neuronal survival by using primary cultures of postnatal rat brain.
KeywordsNerve Growth Factor Cholinergic Neuron ChAT Activity Basal Forebrain Cholinergic Neuron Nerve Growth Factor mRNA
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