Interleukin-6 as a Neurotrophic Factor for Promoting Survival of Septal Cholinergic Neurons and Mesencephalic Catecholaminergic Neurons from Postnatal Rats

  • Tokiko Hama
  • Mami Miyamoto
  • Kaori Noguchi
  • Nobuyuki Takei
  • Hiroko Tsukui
  • Chika Nishio
  • Yoichi Kushima
  • Hiroshi Hatanaka
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Neuronal differentiation and survival are supported by several kinds of neurotrophic factors in the central nervous system (CNS) as in the peripheral nervous system (PNS). The well-known nerve frowth factor (NGF), target derived growth factor, is synthesized1–4 and acts on cholinergic neurons5–12 in the CNS; however the action of NGF on other neurons is limited. We have been studying such factors that act on neuronal survival by using primary cultures of postnatal rat brain.


Nerve Growth Factor Cholinergic Neuron ChAT Activity Basal Forebrain Cholinergic Neuron Nerve Growth Factor mRNA 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tokiko Hama
    • 1
  • Mami Miyamoto
    • 1
  • Kaori Noguchi
    • 1
  • Nobuyuki Takei
    • 2
  • Hiroko Tsukui
    • 3
  • Chika Nishio
    • 3
  • Yoichi Kushima
    • 3
  • Hiroshi Hatanaka
    • 3
  1. 1.Department of NeuroscienceMitsubishi Kasei Institute of Life SciencesMachida-shi, Tokyo 194Japan
  2. 2.National Institute of NeuroscienceNCNPOgawahigashi, Kodaira, Tokyo 187Japan
  3. 3.Institute for Protein ResearchOsaka University 3-2Yamadaoka, Suita, Osaka 565Japan

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