A Hippocampal Cell Line Expresses a Membrane-Associated Cholinergic Trophic Activity Not Attributable to Nerve Growth Factor
Basal forebrain cholinergic cells are prominently affected in Alzheimer’s disease (AD) (Hefti and Weiner, 1986). Choline acetyltransferase (ChAT) is decreased in cholinergic target areas such as the hippocampus and neocortex, and there is a loss of ChAT-positive cells in the basal forebrain, including the septal region. One of the postulated pathogenetic alterations in AD is a deficiency in the normal trophic interactions through which target neocortical and hippocampal cells promote the survival and function of projecting cholinergic neurons (Appel, 1981). Accordingly, trophic factor therapy has been proposed as a potential future approach to the management of AD. Even if abnormalities in trophic interactions do not play a specific pathogenetic role in AD, trophic agents might be expected to help maintain cholinergic innervation of cortex and thus possibly influence the clinical course of AD.
KeywordsPolyethylene Glycol Fluoride Lysine Polypeptide
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