A Striatal-Derived DA Neuron Growth Factor: Implication in Parkinson’s Disease

  • Li Chiung Kao
  • Louis R. Ptak
  • Harold L. Klawans
  • Paul M. Carvey
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


The anti-Parkinsonian efficacy of adrenal medulla-to-brain transplantation was initially thought to result from increased dopamine (DA) secretion from the implanted chromaffin cells. However, examination of the CSF from transplant recipients, failed to demonstrate increased levels of DA despite clinical improvement.1 This would suggest that mechanisms other than increased DA secretion may be responsible for the therapeutic benefits resulting from medulla transplantation. Any alternative hypothesis advanced must consider recent observations suggesting that: 1- endogenous DA tone appears increased by medulla transplantation,3 2- transplantatiort leads to enhanced sprouting of tyrosine hydroxylase positive f hers,6 and 3- transplantation results in bilateral clinical improvement.5 The release of a neuro-trophic-factor (NTF) capable of diffusing through CSF is consistent with these observations.


Nerve Growth Factor Tyrosine Hydroxylase Neuron Growth Striatal Tissue AMPH Treatment 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Li Chiung Kao
    • 1
  • Louis R. Ptak
    • 1
  • Harold L. Klawans
    • 1
  • Paul M. Carvey
    • 1
  1. 1.Neuropharmacology Research Laboratories, Rush PresbyterianSt. Lukes Medical Center ChicagoUSA

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