Nerve Growth Factor Promotes Survival of Cultured Cholinergic Neurons from Nucleus Basalis of Meynert of 2-Week-Old Rats

  • Hiroshi Hatanaka
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


One of the possible causes of Alzheimer’s disease is thought to be a lack of nerve growth factor (NGF), a molecule that plays an important role in the neuronal differentiation and cell survival of basal forebrain cholinergic neurons.1 These neurons are scattered over the following three areas: medial septum nucleus, diagonal band of Broca (vertical and horizontal limbs), and nucleus basalis of Meynert. The action of NGF on cells in the former two regions has already been investigated in detail.2–6 However, its action on the cholinergic neurons in the nucleus basalis of Meynert has not been investigated extensively. The reason for this sparse research might be that, in the rat and many other experimental animals, detection and isolation of the cholinergic neurons of this nucleus are difficult. In this communication, we measured the number of viable cholinergic neurons in cultures of the nucleus with or without NGF.7,8. This is the first. report on the effects of NGF on the functions of cultured cholinergic neurons of the nucleus basalis of Meynert from postnatal 2-week-old rats.


Nerve Growth Factor Cholinergic Neuron Basal Forebrain Nucleus Basalis Nerve Growth Factor Receptor 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hiroshi Hatanaka
    • 1
  1. 1.Institute for Protein ResearchOsaka UniversitySuita-shi, Osaka 565Japan

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