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Alteration of [3H] Ins (1,4,5) P3 and [3H] PDBu Binding Sites in Brains of Patients with Parkinson’s Disease and Multiple System Atrophy

  • Takeshi Hashimoto
  • Yasuo Kajimoto
  • Yutaka Shirai
  • Naoya Murakami
  • Naoki Nishino
  • Seiji Noguchi
  • Osamu Komure
  • Sadako Kuno
  • Norio Sakai
  • Noboru Kitamura
  • Chikako Tanaka
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The roles of membrane inositol phospholipid turnover in intracellular signal transduction have been vigorously researched. Stimulation of several receptors by neurotransmitters, hormones, and growth factors leads to accelerated turnover of polyphosphoinositides. Hydrolysis of phosphatidylinositol 4,5-bisphosphate by activated phospholipase C generates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and 1,2-diacylglycerol, both of which act as second messengers. The former increases intracellular Ca2+ and the latter activates protein kinase C (PKC) (Nishizuka, 1986).

Keywords

Multiple System Atrophy Caudate Nucleus Multiple System Atrophy Patient Neuronal Cell Loss Pallidal Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Takeshi Hashimoto
    • 3
  • Yasuo Kajimoto
    • 3
  • Yutaka Shirai
    • 3
  • Naoya Murakami
    • 3
  • Naoki Nishino
    • 3
  • Seiji Noguchi
    • 2
  • Osamu Komure
    • 1
  • Sadako Kuno
    • 1
  • Norio Sakai
  • Noboru Kitamura
  • Chikako Tanaka
  1. 1.Department of NeurologyUtano National Hospital KyotoKobe 650Japan
  2. 2.Department of Biological ResearchCiba-Geigy TakarazukaKobe 650Japan
  3. 3.Department of Neurology and Psychiatry Department of PharmacologyKobe University School of MedicineKobe 650Japan

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