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More Rapid Development of Supersensitivity of D-2 Receptors than D-1 Receptors as Examined by Rotational Behavior

  • Eiji Mizuta
  • Sadako Kuno
  • Hidehiko Nabatame
  • Akinori Akaike
  • Masashi Sasa
  • Shuji Takaori
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Injection of a dopamine agonist such as apomorphine induces rotation of the rat given 6-hydroxydopamine (6-OHDA) in the nigrostriatal pathway, because destruction of dopaminergic pathway causes supersensitivity of the dopaminergic receptors innervated by these fibers (Ungerstedt, 1971; Creese et al., 1977). This rotation is reported to be induced by both DA D-1 and D-2 agonists. However, whether the rotation induced by DA agonists is due to the distinct action on D-1 and D-2 receptors or synergic interaction between D-1 and D-2 receptors is unknown (Herrera-Marschitz and Ungerstedt, 1984, 1985: Arnt and Hyttel, 1984, 1985; Arnt and Perregaard, 1987; Morelli et al., 1987; Karlsson et al., 1988; Casas et al., 1989). In addition, a little is known regarding the time course of development of supersensitivity of distinct D-1 and D-2 receptors after lesion of the dopaminergic pathway. We examined the role of D-1 and D-2 receptors in rotational behavior and the time course of appearance of supersensitivity of D-1 and D-2 receptors using selective D-1 and D-2 agonists as well as antagonists.

Keywords

Substantia Nigra Dopamine Agonist Rotational Behavior Nigrostriatal Pathway Dopaminergic Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Eiji Mizuta
    • 1
    • 2
  • Sadako Kuno
    • 2
  • Hidehiko Nabatame
    • 1
  • Akinori Akaike
    • 1
  • Masashi Sasa
    • 1
  • Shuji Takaori
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineKyoto UniversityKyoto 606Japan
  2. 2.Department of NeurologyUtano National HospitalKyoto 616Japan

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