Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer’s Disease
Amyloid deposits occur in the forms of senile plaques (SP’s), amyloid angiopathy(AA), and plaque-like vascular changes in the brains of Alzheimer’s disease (Alz) patients. These pathological changes are important since the occurrence of these structures is correlated with the severity of the dementia. A protein consisting of 42–43 amino acids and with a molecular weight of about 4000 kd, designated as amyloid A41 or β-protein,2 has been isolated as a component of amyloid protein (Am) from AA in the Alz brain. The same A4 protein as in AA is also found commonly in various types of SP’s in Alz and Down’s syndrome.
KeywordsDown Syndrome Amyloid Deposit Amyloid Plaque Senile Plaque Amyloid Protein
Unable to display preview. Download preview PDF.
- 2.G. G. Glenner, and C. W. Wong, Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120: 885 (1984).Google Scholar
- 8.D. J. Selkoe, M. B. Podlisny, C. L. Joachim, E. A. Vickers, G. Lee, L.C. Fritz, and T. Oltersdolf, Amyloid precursor protein of Alzheimer disease occurs as 110- to 135 kilodalton membrane-associated proteins in neural and nonneural tissues, Proc. Natl. Acad. Sci.USA 85: 7341 (1988).PubMedCrossRefGoogle Scholar
- 9.H. Kawasaki, M. Utsuyama, S. Kubo, E. Moriizumi, S. Handa, K. Shigemoto, N. Ishikawa, Y. Hayashi, Y. Esaki, N. Maruyama, and K. Hirokawa, Production of monoclonal antibody against senile plaques in the human brain and its immunohistochemical application, J. Clin. Exp. Med. (Igaku no ayumi) 143: 101 (1987).Google Scholar
- 10.T. Ishii, and S. Haga, Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques, Acta. Neuropathol.(Berl.) 63: 296 (1984).Google Scholar