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Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer’s Disease

  • Yuji Aizawa
  • Ryo Fukatsu
  • Yuji Takamaru
  • Kayo Tsuzuki
  • Tosyiyuki Obara
  • Mitsuru Fujii
  • Mikiho Kobayashi
  • Naohiko Takahata
  • Toshihiko Gotoda
  • Shigeharu Nagasawa
  • Keiji Oguma
  • Tatsuhide Kunishita
  • Takeshi Tabira
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Amyloid deposits occur in the forms of senile plaques (SP’s), amyloid angiopathy(AA), and plaque-like vascular changes in the brains of Alzheimer’s disease (Alz) patients. These pathological changes are important since the occurrence of these structures is correlated with the severity of the dementia. A protein consisting of 42–43 amino acids and with a molecular weight of about 4000 kd, designated as amyloid A41 or β-protein,2 has been isolated as a component of amyloid protein (Am) from AA in the Alz brain. The same A4 protein as in AA is also found commonly in various types of SP’s in Alz and Down’s syndrome.

Keywords

Down Syndrome Amyloid Deposit Amyloid Plaque Senile Plaque Amyloid Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Yuji Aizawa
    • 1
  • Ryo Fukatsu
    • 1
  • Yuji Takamaru
    • 3
  • Kayo Tsuzuki
    • 2
  • Tosyiyuki Obara
    • 3
  • Mitsuru Fujii
    • 1
  • Mikiho Kobayashi
    • 1
  • Naohiko Takahata
    • 1
  • Toshihiko Gotoda
    • 3
  • Shigeharu Nagasawa
    • 4
  • Keiji Oguma
    • 2
  • Tatsuhide Kunishita
    • 5
  • Takeshi Tabira
    • 5
  1. 1.Dept. of NeuropsychiatrySapporo Medical CollegeJapan
  2. 2.Dept. of MicrobiologySapporo Medical CollegeJapan
  3. 3.Dept. of PsychiatryHokkaido UniversitySapporoJapan
  4. 4.Dept. of PharmacologyHokkaido UniversitySapporoJapan
  5. 5.National Center for Nervous, Mental, and Muscle DisordersTokyoJapan

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