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Age-Dependent Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in the Rat

  • Klaus W. Lange
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a Parkinsonian syndrome in humans and monkeys which is accompanied by degeneration of dopamine containing neurones in the substantia nigra pars compacta (SNC) and extensive loss of dopamine in the striatum (for review see Langston, 1987). Rats are much less sensitive to the neurotoxicity of MPTP than primates. Systemic administration of MPTP to rats did not produce neurotoxic effects (Chiueh et al., 1984) and intranigral administration failed to induce lasting damage to the SNC neurones (Chiueh et al., 1984; Bradbury et al., 1986) or lasting behavioural effects (Welzl and Lange, 1986). The neurotoxicity of MPTP seems to be age-dependent. It has been demonstrated that old mice suffer more extensive neuronal damage in the SNC than younger animals in response to MPTP administration (Gupta et al., 1986). The present experiment studied the age-dependent effects of unilateral intranigral administration of MPTP in the rat.

Keywords

Nigrostriatal Dopamine MPTP Administration MPTP Injection Striatal Dopamine Depletion Lasting Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Klaus W. Lange
    • 1
    • 2
  1. 1.University Department of Neurology and Parkinson’s Disease Society Research CentreInstitute of Psychiatry and King’s College School of MedicineLondonUK
  2. 2.Laboratory of Psychobiology Institute of PsychologyUniversity of DüsseldorfDüsseldorfGermany

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