M1 Receptors Stimulate Dopamine Release Via Protein Kinase C in the Striatum of Freely Moving Rat Studied by Brain Dialysis
Recent binding and autoradiographic studies have demonstrated that muscarinic receptors in the central and peripheral nervous systems are divided into four subtypes, i.e., M1, M2, M3, and M4. One of various classifications is based on the use of the muscarinic antagonist pirenzepine. The M1-type receptors have a high affinity for pirenzepine, whilst the M2- and M3- types have a low pirenzepine affinity. Muscarinic receptors in the brain may have very important physiological roles. Especially, the receptors in patients with Alzheimer’s and Parkinson’s diseases may dysfunction. Our recent study indicated that in vivo striatal dopamine (DA) release is stimulated by M1 receptors located on the striatal DA terminals.1
KeywordsAdenylate Cyclase Muscarinic Receptor Dopamine Release Striatal Dopamine Important Physiological Role
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