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The Influence of Priming on the Behavioral Expression of Dopamine Receptor Supersensitivity in Basal Ganglia

  • Micaela Morelli
  • Sandro Fenu
  • Alberto Cozzolino
  • Gaetano Di Chiara
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The D-1 agonist SKF 38393 (2 mg/kg s.c.) failed to induce contralateral turning in drug-naive rats, lesioned unilaterally with 6-hydroxydopamine (6-OHDA) from 17 days, while elicited intense contralateral turning 90 days post lesion. Priming with a single administration of a dopaminergic (DA) agonist which elicited contralateral turning by itself, made SKF 38393 very active in producing contralateral turning in rats, lesioned with 6-OHDA from 17 days. The effectiveness of the D-1/D-2 agonist apomorphine as a primer of SKF 39393 induced turning was critically dependent on the interval between the administration of the two agonists. Effectiveness was minimal with an interval of 3 h, increased after 6–12 h, peaking at 72 h and was reduced after 10 days. Priming took place also when the primer and SKF 38393 were administered in different environment, indicating that priming in not dependent from behavioral conditioning. Finally, administration of the N-Methyl-D-Aspartate (NMDA) receptor antagonist (+) MK 801 in conjunction with apomorphine prevented its ability to act as a primer, indicating that the NMDA receptors exert a permissive role on priming.

Keywords

Permissive Role Receptor Supersensitivity Agonist Apomorphine Ineffective Dose Behavioral Conditioning 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Amt, J. and Hyttel, J., 1984, Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions, European J. Pharmacol., 102: 349.CrossRefGoogle Scholar
  2. Barone, P., Davis, T.A., Brain, A.R. and Chase, T.N., 1986, Dopaminergic mechanisms and motor function: characterization of D-1 and D-2 dopamine receptor interactions, European J. Pharmacol.,. 123: 109.CrossRefGoogle Scholar
  3. Gershanik, O., Heikkila, R.E. and Duvoisin, R.C., 1983, Behavioural correlations of dopamine receptor activation, Neurology, 33: 1489.PubMedCrossRefGoogle Scholar
  4. Herrera-Marsschitz, M. and Ungerstedt, U., 1984, Evidence that apomorphine and pergolide induce rotation in rats by different actions on D-1 and D-2 receptor sites, European J. Pharmacol., 98: 165.CrossRefGoogle Scholar
  5. Longoni, R., Spina, L. and Di Chiara, G., 1987a, Permissive role of D-1 receptor stimulation by endogenous dopamine for the expression of postsynaptic D-2-mediated behavioural responses. Yawning in rats, European J. Pharmacol., 134: 163.CrossRefGoogle Scholar
  6. Longoni, R., Spina, L. and Di Chiara, G., 1987b, Permissive role of D-1 receptor stimulation for the expression of D-2 mediated behavioural responses: a quantitative phenomenological study in rats, Life Sci., 41: 2135.PubMedCrossRefGoogle Scholar
  7. Morelli, M. and Di Chiara, G., 1987a, Agonist-induced homologous and heterologous sensitization to D-1 and D-2 dependent contraversive turning, European J. Pharmacol., 141: 101.CrossRefGoogle Scholar
  8. Morelli, M., Fenu, S. and Di Chiara, G., 1987b, Behavioural expression of D-1 receptor supersensitivity depends on previous stimulation of D-2 receptors, Life Sci., 40: 245.PubMedCrossRefGoogle Scholar
  9. Morelli, M., Fenu,S., Garau, L., and Di Chiara, G., 1989, Time and dose dependence of the priming of the expression of dopamine receptor supersensitivity, European J. Pharmacol., 162: 329.CrossRefGoogle Scholar
  10. Silverman, P.B., and Ho, B.T., 1981, Persistent behavioral effect of apomorphine in 6hydroxydopamine lesioned rats, Nature, 294: 475.PubMedCrossRefGoogle Scholar
  11. Ungerstedt, U., 1971, Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system, Acta Physiol. Scand., 376, 1.Google Scholar
  12. Wong, E.H.F., Knight, A.R. and Woodruff, G.N., 1988, [3H] MK 801 labels a site on the N-Methyl D-Aspartate receptor channel complex in rat brain membranes, J. Neurochem., 50: 274.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Micaela Morelli
    • 1
  • Sandro Fenu
    • 1
  • Alberto Cozzolino
    • 1
  • Gaetano Di Chiara
    • 1
  1. 1.Institute of Experimental Pharmacology and ToxicologyUniversity of CagliariItaly

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