Abstract
In this short report, we will describe the Onding charagteristics of [3H] N- (1- [2-thienyl] cyclohexyl) 3, 4-piperidine ([ 3H] TCP) and [3H] glutamate to membrane preparations obtained from postmortem human frontal cortical tissues. Under the assay conditions adopted to eliminate the possible effects of endogeneous substances on the bining parameters, we found significant decreases either in [3H]TCP or [3H]glutamate binding capacity in Alzheimer’s disease (AD) postmortem brains.
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© 1990 Plenum Press, New York
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Shimohama, S., Ninomiya, H., Kameyama, M. (1990). Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer’s Disease Frontal Cortex. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_115
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_115
Publisher Name: Springer, Boston, MA
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