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Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer’s Disease Frontal Cortex

  • Shun Shimohama
  • Haruaki Ninomiya
  • Masakuni Kameyama
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

In this short report, we will describe the Onding charagteristics of [3H] N- (1- [2-thienyl] cyclohexyl) 3, 4-piperidine ([ 3H] TCP) and [3H] glutamate to membrane preparations obtained from postmortem human frontal cortical tissues. Under the assay conditions adopted to eliminate the possible effects of endogeneous substances on the bining parameters, we found significant decreases either in [3H]TCP or [3H]glutamate binding capacity in Alzheimer’s disease (AD) postmortem brains.

Keywords

NMDA Receptor Membrane Preparation Excitatory Amino Acid Receptor Glutamate Binding Cortical Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shun Shimohama
    • 1
  • Haruaki Ninomiya
    • 1
    • 2
  • Masakuni Kameyama
    • 3
  1. 1.Departments of Neurology, Faculty of MedicineKyoto UniversityKyoto 606Japan
  2. 2.Departments of Pharmacology, Faculty of MedicineKyoto UniversityKyoto 606Japan
  3. 3.Department of NeurologySumitomo HospitalOsaka 530Japan

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