Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer’s Disease Frontal Cortex
In this short report, we will describe the Onding charagteristics of [3H] N- (1- [2-thienyl] cyclohexyl) 3, 4-piperidine ([ 3H] TCP) and [3H] glutamate to membrane preparations obtained from postmortem human frontal cortical tissues. Under the assay conditions adopted to eliminate the possible effects of endogeneous substances on the bining parameters, we found significant decreases either in [3H]TCP or [3H]glutamate binding capacity in Alzheimer’s disease (AD) postmortem brains.
KeywordsNMDA Receptor Membrane Preparation Excitatory Amino Acid Receptor Glutamate Binding Cortical Membrane
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