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Cerebellar Excitatory Amino Acid Binding Sites are Differentially Altered in Alzheimer’s Disease

  • Deborah Dewar
  • Derek Chalmers
  • Akeo Kurumaji
  • David Graham
  • James McCulloch
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Summary

Excitatory amino acid binding sites in the cerebellum were differentially altered and preserved in Alzheimer’s Disease. Quisqualate receptor binding was markedly reduced in the molecular layer while glycine receptor binding was increased in the granule cell layer of Alzheimer cerebellar cortex, compared to age-matched controls. Markers for presynaptic excitatory amino acid terminals, kainate and N-methyl-D-aspartate receptors were unchanged in the same Alzheimer patients. Neuritic plaques were present in the cerebellar cortex in two of the Alzheimer patients. The results suggest that the cerebellum is not spared by the pathophysiological process of Alzheimer’s Disease.

Keywords

NMDA Receptor Purkinje Cell Molecular Layer Cerebellar Cortex Excitatory Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chalmers, D., Dewar, D., Kurumaji, A, Graham, D. and McCulloch J. (this volume)Google Scholar
  2. Cole, G., Williams, P., Alldryck, D. and Singharo, S. (1989) Clin. Neuropathol. 8 188–191.PubMedGoogle Scholar
  3. Cowburn, R., Hardy, J., Roberts, P. and Briggs, R. (1988) Brain Res. 452 403–407.PubMedCrossRefGoogle Scholar
  4. Olson, J.M.M., Greenamyre, J.T., Penney, J.B. and Young, A.B. (1987) Neurosci. 22 913–923.CrossRefGoogle Scholar
  5. Simpson, M.D.C., Royston, M.C., Deakin, J.F.W., Cross, A.J., Mann, D.M.A. and Slater, P. (1988) Brain Res. 462 76–82.PubMedCrossRefGoogle Scholar
  6. Terry, R.D., Peck, A., DeTeresa, R., Schechter, R. and Horoupian, D.S. (1981) Ann. Neurol. 10 184–192.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Deborah Dewar
    • 1
  • Derek Chalmers
    • 1
  • Akeo Kurumaji
    • 1
  • David Graham
    • 1
  • James McCulloch
    • 1
  1. 1.Wellcome Surgical Institute & Hugh Fraser Neuroscience LaboratoriesUniversity of GlasgowGlasgowUK

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