Cerebellar Excitatory Amino Acid Binding Sites are Differentially Altered in Alzheimer’s Disease
Excitatory amino acid binding sites in the cerebellum were differentially altered and preserved in Alzheimer’s Disease. Quisqualate receptor binding was markedly reduced in the molecular layer while glycine receptor binding was increased in the granule cell layer of Alzheimer cerebellar cortex, compared to age-matched controls. Markers for presynaptic excitatory amino acid terminals, kainate and N-methyl-D-aspartate receptors were unchanged in the same Alzheimer patients. Neuritic plaques were present in the cerebellar cortex in two of the Alzheimer patients. The results suggest that the cerebellum is not spared by the pathophysiological process of Alzheimer’s Disease.
KeywordsNMDA Receptor Purkinje Cell Molecular Layer Cerebellar Cortex Excitatory Amino Acid
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- Chalmers, D., Dewar, D., Kurumaji, A, Graham, D. and McCulloch J. (this volume)Google Scholar