Dementia in Parkinson’s Disease and Central Cholinergic Function
Dementia occurs in a significant number of patients with Parkinson’s disease without substantial pathological changes typical of Alzheimer’s disease, i.e. they do not show a higher number of senile plaques and neurofibrillary tangles in the cerebral cortex than those expected by age alone (Candy et al., 1983; Perry et al., 1985). While much is known about the central biochemical changes causing the movement disorders in Parkinsonian subjects (Agid et al., 1989), the neurochemical basis of cognitive impairment and dementia is less clear.
KeywordsMuscarinic Receptor Temporal Cortex Cholinergic System Muscarinic Cholinergic Receptor Choline Acetyltransferase Activity
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