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Patterns of Tyrosine and Tryptophan Metabolites in Controls and Various Degenerative Disorders

  • Edward D. Bird
  • Wayne R. Matson
  • M. Flint Beal
  • Tatsuji Ogawa
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Over the last few years, we have been applying techniques for generating and analyzing complex patterns of several hundred small biological molecules to neurodegenerative disorders. The general hypothesis emerging from this work is that patterns of small molecular species are an operational expression of the genome. Under this hypothesis, we would argue that: (1) the underlying genetic makeup of an individual determining their variability in such features as morphology and patterns of enzymes will be reflected through these features in the levels and interrelationships of small molecular species such as transmitters, precursors, metabolites, cofactors; and (2) an individual with a particular degenerative or affective disorder will exhibit a pattern of small molecules that is uniquely different from both normals and other disorders.

Keywords

Kynurenic Acid Linear Multiple Regression Homogentisic Acid Tryptophan Metabolite Small Biological Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Beal MF, Matson WR, Swartz KJ, Gamache PH and Bird ED. Kynurenine Pathway Measurements in Huntington’s Disease Striatum; Evidence for Reduced Formation of Kynurenic Acid. J. Neurochemistry, submitted.Google Scholar
  2. 2.
    Swartz KY, Matson WR, MacGarvey U and Beal MF. Measurement of Kynurenic Acid in Mammalian Brain Extracts and Cerebral Spinal Fluid by High Performance Liquid Chromatography with Fluorescence Detection. J. Neurochemistry, submitted.Google Scholar
  3. 3.
    Bouckoms AJ, Sweet WH, Poletti C, Lavori P, Carr D, Matson W, Gamache PHand Aronin N. Monoamines in the Brain Cerebrospinal Fluid of Facial Pain Patients. Anesthesia, submitted.Google Scholar
  4. 4.
    Matson WR, Gamache PH, Beal MF and Bird ED. EC Array Concepts and Data. Life Sciences, 41, 7, 905–908, 1987.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Edward D. Bird
    • 1
  • Wayne R. Matson
    • 2
  • M. Flint Beal
    • 1
  • Tatsuji Ogawa
    • 1
  1. 1.Harvard Medical SchoolBostonUSA
  2. 2.ESA, Inc.BedfordUSA

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