Examination of Central Nervous System Effects of Amphetamine Using NEUBA®
A brief review of the literature indicates that d-(+)-amphetamine is one of the most heavily investigated CNS stimulants (Kuczenski, 1983). The mode of action of this compound is inevitably connected to, at least, catecholaminergic pathways. The well-known behavioral actions of amphetamine, including locomotor stimulation and stereopathy, can be readily blocked by surgical removal or pharmacological blockade of specific catecholaminergic pathways in the CNS. On the other hand, the involvement of alternative neurotransmitter pathways in the expression of amphetamine psychostimulant effects is relatively less well investigated.
KeywordsCentral Nervous System Stimulant Amphetamine Treatment Dopa Accumulation Dopa Decarboxylase Inhibitor Neostriatal Neuron
Unable to display preview. Download preview PDF.
- Chapman, D., Obianwu, H., and Howard, S., 1989, Effects of amphetamine or parahydroxy-amphetamine on the behavior and dopamine levels in the neostriatum of the rat, Soc. Neurosci. Abstr., 15: 1066.Google Scholar
- Deminière, J.M., Piazza, P.V., Maccari, S., Le Moal, M., Mormède, P., and Simon, H., 1989, Individual differences in acquisition of amphetamine self-administration is correlated with behavioral and endocrinological response to stress, Soc. Neurosci. Abstr., 15: 1186.Google Scholar
- Heikkila, R.E., Orlansky, H., and Cohen, G., 1975, Studies on the distinction between uptake inhibition and release of 3H-dopamine in rat brain tissue slices, Biochem. Pharmacol., 24: 852.Google Scholar
- Kuczenski, R. (1983) Biochemical actions of amphetamine and other stimulants, in: “Stimulants: Neurochemical, Behavioral & Clinical Perspectives”, I. Creese, ed., Raven Press, New York, pp. 31–61.Google Scholar
- Rebec, G.D., Kraft, M.E., Langley, P.E., and Ciancone, M.T. (1989) In vivo voltammetry in the neostriatum of freely moving rats: monitoring extracellular ascorbate and DOPAC during acute and chronic amphetamine, Soc. Neurosci. Abstr., 15: 558.Google Scholar
- Stein, W.B., 1967, “The Movement of Molecules Across Cell Membranes”, vol. 6, Academic Press, New York.Google Scholar
- Tschanz, J.T., Haracz, J.L., Griffith, K.E., and Rebec, G.V., 1989, Single-unit activity in the neostriatum of freely moving rats: effects of cortical lesions on the behavioral and neuronal responses to amphetamine and neuroleptics, Soc. Neurosci. Abstr., 15: 1133.Google Scholar
- Wichlinski, L.J., Gordon, J.H., Siegel, R.L., Charkatz, P., and Fields, J.Z., 1989, Transient behavioral defecits following neurotoxic doses of amphetamine, Soc. Neurosci. Abstr. 15: 1317.Google Scholar