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Generating and Controlling Multiparameter Data Bases for Biochemical Correlates of Disorders

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Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 38A))

Abstract

Perhaps the most powerful potential use of multiparameter biochemical data bases in studies of degenerative disorders is the unique discrimination of categories. The technology of Coulometric Array Electrode Systems (CEAS) can automatically resolve approximately 400 compounds from biological samples at the picogram level. Among these are tyrosine and tryptophan derived neurotransmitters, precursors, metabolites, conjugates and cofactors, certain purines, pterins and neuropeptides. This capability offers the promise of generating enough relevant data to describe disorders.

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References

  1. Bouckoms AJ, Sweet WH, Poletti C, Lavori P, Carr D, Matson W, Gamache PH and Aronin N. Monoamines in the Brain Cerebrospinal Fluid of Facial Pain Patients. Anesthesia, submitted.

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  2. Beal MF, Matson WR, Swartz KJ, Gamache PH and Bird ED. Kynurenine,Pathway Measurements in Huntington’s Disease Striatum; Evidence for Reduced Formation of Kynurenic Acid. J. Neurochemistry, submitted.

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  3. Bird ED, Matson WR, Beal MF and Ogawa T. Patterns of Tyrosine and Tryptophan Metabolites in Controls and Various Degenerative Disorders. Paper presented at the Alzheimer’s and Parkinson’s Disease Conference, Kyoto, Japan, November 6–10, 1989.

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Author information

Authors and Affiliations

  1. ESA, Inc., Bedford, MA, USA

    Wayne R. Matson & Clive Svendsen

  2. Harvard Medical School, Boston, MA, USA

    Anthony Bouckoms, M. Flint Beal & Edward D. Bird

Authors
  1. Wayne R. Matson
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  2. Anthony Bouckoms
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  3. Clive Svendsen
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  4. M. Flint Beal
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  5. Edward D. Bird
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Editor information

Editors and Affiliations

  1. Nagoya University School of Medicine, Nagoya, Japan

    Toshiharu Nagatsu

  2. Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher

  3. Jichi Medical School, Tochigi, Japan

    Mitsuo Yoshida

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© 1990 Plenum Press, New York

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Matson, W.R., Bouckoms, A., Svendsen, C., Beal, M.F., Bird, E.D. (1990). Generating and Controlling Multiparameter Data Bases for Biochemical Correlates of Disorders. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_103

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  • DOI: https://doi.org/10.1007/978-1-4684-5844-2_103

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5846-6

  • Online ISBN: 978-1-4684-5844-2

  • eBook Packages: Springer Book Archive

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