Generating and Controlling Multiparameter Data Bases for Biochemical Correlates of Disorders

  • Wayne R. Matson
  • Anthony Bouckoms
  • Clive Svendsen
  • M. Flint Beal
  • Edward D. Bird
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Perhaps the most powerful potential use of multiparameter biochemical data bases in studies of degenerative disorders is the unique discrimination of categories. The technology of Coulometric Array Electrode Systems (CEAS) can automatically resolve approximately 400 compounds from biological samples at the picogram level. Among these are tyrosine and tryptophan derived neurotransmitters, precursors, metabolites, conjugates and cofactors, certain purines, pterins and neuropeptides. This capability offers the promise of generating enough relevant data to describe disorders.

Keywords

Dopamine Tyrosine Tryptophan Purine Monoamine 

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References

  1. 1.
    Bouckoms AJ, Sweet WH, Poletti C, Lavori P, Carr D, Matson W, Gamache PH and Aronin N. Monoamines in the Brain Cerebrospinal Fluid of Facial Pain Patients. Anesthesia, submitted.Google Scholar
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    Beal MF, Matson WR, Swartz KJ, Gamache PH and Bird ED. Kynurenine,Pathway Measurements in Huntington’s Disease Striatum; Evidence for Reduced Formation of Kynurenic Acid. J. Neurochemistry, submitted.Google Scholar
  3. 3.
    Bird ED, Matson WR, Beal MF and Ogawa T. Patterns of Tyrosine and Tryptophan Metabolites in Controls and Various Degenerative Disorders. Paper presented at the Alzheimer’s and Parkinson’s Disease Conference, Kyoto, Japan, November 6–10, 1989.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Wayne R. Matson
    • 1
  • Anthony Bouckoms
    • 2
  • Clive Svendsen
    • 1
  • M. Flint Beal
    • 2
  • Edward D. Bird
    • 2
  1. 1.ESA, Inc.BedfordUSA
  2. 2.Harvard Medical SchoolBostonUSA

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