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Possible Factors Responsible for Adverse Effects of Long-Term L-Dopa Therapy: Simultaneous Determinations of Dopamine Parameters in Rats

  • Miho Murata
  • Kenji Yoneda
  • Ichiro Kanazawa
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

After initial benefit, many adverse effects, i.e., “wearing-off”, “on-off”, or dyskinesia develop following long-term l-dopa therapy. Especially, causes of “wearing-off”, which is the most common adverse effect, are proposed to be 1) alterations of l-dopa absorption from the gut, 2) a reduction in l-dopa transport across the blood-brain barrier, 3) changes in dopamine (DA) distribution and metabolism in the CNS, and 4) modification of striatal DA receptor activity.1

Keywords

Tyrosine Hydroxylase Repeated Administration Single Administration Tyrosine Hydroxylase Activity Average Initial Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Miho Murata
    • 1
  • Kenji Yoneda
    • 1
  • Ichiro Kanazawa
    • 1
  1. 1.Department of Neurology, Institute of Clinical MedicineUniversity of TsukubaTsukuba-City, 305Japan

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