Possible Factors Responsible for Adverse Effects of Long-Term L-Dopa Therapy: Simultaneous Determinations of Dopamine Parameters in Rats
After initial benefit, many adverse effects, i.e., “wearing-off”, “on-off”, or dyskinesia develop following long-term l-dopa therapy. Especially, causes of “wearing-off”, which is the most common adverse effect, are proposed to be 1) alterations of l-dopa absorption from the gut, 2) a reduction in l-dopa transport across the blood-brain barrier, 3) changes in dopamine (DA) distribution and metabolism in the CNS, and 4) modification of striatal DA receptor activity.1
KeywordsTyrosine Hydroxylase Repeated Administration Single Administration Tyrosine Hydroxylase Activity Average Initial Body
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- 1.D. B. Calne, P. F. Teychenne, and R. F. Pfeiffer, in: “Parkinson’s Disease; Neurophysiological, Clinical and Related Aspects,” F.A. Messiha and A. Kenny, eds., Plenum Press, New York (1977).Google Scholar