Abstract
After initial benefit, many adverse effects, i.e., “wearing-off”, “on-off”, or dyskinesia develop following long-term l-dopa therapy. Especially, causes of “wearing-off”, which is the most common adverse effect, are proposed to be 1) alterations of l-dopa absorption from the gut, 2) a reduction in l-dopa transport across the blood-brain barrier, 3) changes in dopamine (DA) distribution and metabolism in the CNS, and 4) modification of striatal DA receptor activity.1
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© 1990 Plenum Press, New York
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Murata, M., Yoneda, K., Kanazawa, I. (1990). Possible Factors Responsible for Adverse Effects of Long-Term L-Dopa Therapy: Simultaneous Determinations of Dopamine Parameters in Rats. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_102
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_102
Publisher Name: Springer, Boston, MA
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