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Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene

  • Shun-ichi Yoshikai
  • Hiroyuki Sasaki
  • Katumi Doh-ura
  • Hirokazu Furuya
  • Yoshiyuki Sakaki
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Amyloid ß protein in Alzheimer’s brain is a cleavage product of the precursor protein (BPP). The sequence analysis of its BPP cDNA showed that BPP resembles a cell-surface receptor (Kang et al., 1987) and that there are three types of BPP mRNA generated by alternative splicing, two of which encode a serine-protease inhibitor (serpin) domain (Kitaguchi et al., 1988, Ponte et al., 1988, Tanzi et al, 1988).

Keywords

Alternative Splice Splice Acceptor Site Amyloid Protein Precursor mRNA Protease Inhibitor Domain Human Genomic Library 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shun-ichi Yoshikai
    • 1
  • Hiroyuki Sasaki
    • 1
  • Katumi Doh-ura
    • 2
  • Hirokazu Furuya
    • 1
  • Yoshiyuki Sakaki
    • 1
  1. 1.Research Laboratory for Genetic InformationJapan
  2. 2.Department of NeuropathologyFaculty of Medicine Kyushu UniversityFukuoka 812Japan

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