Abstract
Amyloid ß protein in Alzheimer’s brain is a cleavage product of the precursor protein (BPP). The sequence analysis of its BPP cDNA showed that BPP resembles a cell-surface receptor (Kang et al., 1987) and that there are three types of BPP mRNA generated by alternative splicing, two of which encode a serine-protease inhibitor (serpin) domain (Kitaguchi et al., 1988, Ponte et al., 1988, Tanzi et al, 1988).
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Kang, J., Lemire, H., Unterbeck, A., Salbaum, J. M., Masters, C. L, Grzeshik, K., Multhaup, G., Beyreuther, D. and Müller-Hill, B., 1987, The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature, 325: 733–736
Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S. and Ito, H., 1988, Novel precursor of Alzheimer’s disease amyolid protein shows protease inhibitory acitivity. Nature, 331: 530–532
Krainer, A. R. and Maniatis, T., 1988, “Transcription and splicing” IRL Press, Eynsham, Oxford, England
Lemire, H. G., Salbaum, J. M., Multhaup, G., Kang, J., Bayney, R. M., Unterbeck, A., Beyreuther, K. and Müller-Hill, B.,1989, The preA4695 precursor protein of Alzheimer’s diease A4 amyloid is encoded by 16 exons. Nuc. Acid Res., 17:517–522
Ponte, P., Gonzalez-DeWhitt, P., Schilling, J., Miller, J., Hsu, D., Greenberg, B., Davis, K., Wallance, W., Lieberburg, I., Fuller, F. and Cordell, 1988, A new A4 amyloid RNA contains a domain homologous to serine proteinase inhibitors. Nature, 331: 525–527
Salbaum, J. M., Weidemann, A., Lemire, H., Masters, C. L. and Beyreuther, K.,1988, The promoter of Alzheimer’s disease amyloid A4 precursor gene. EMBO J., 7: 2807–2813
Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa-Komaroff, L., Gusella, J. F. and Neve, R. L., 1988, Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer’s disease., Nature, 331: 528–530
Yoshikai, Y., Sasaki, H., Doh-ura, K., Furuya, H. and Sakaki, Y., 1989, Gene, in press
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© 1990 Plenum Press, New York
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Yoshikai, Si., Sasaki, H., Doh-ura, K., Furuya, H., Sakaki, Y. (1990). Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_10
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_10
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