Functional Principles Implied in Neurological Symptoms
Characteristic symptoms of a neurological disease should reflect a specific mechanism with which brain tissues normally operate. One may hope that a rigorous analysis of such symptoms will easily reveal mechanisms of the central nervous system. However, looking at the history of neurology and neurophysiology, it is clear that this is not an easy task. There are two obvious reasons for this difficulty. First, to trace from results back to a cause is in general much harder than to deduce results from a cause. Once a central mechanism is known, it will be relatively easy to understand symptoms derived from its disturbance, but without knowing the central mechanism, symptoms would just be puzzling. Second, central mechanisms causal to neurological symptoms are in fact highly complex and in most cases, of unknown nature to any field of science.
KeywordsBasal Ganglion Purkinje Cell Mossy Fiber Feedforward System Purkinje Cell Synapse
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