A Primer of Permeation and Gating
We are in the midst of an explosive interest in ion channels. This is due to three factors. First, ion channels have been discovered in virtually every type of cell, not just in nerve and muscle cells, the classical “excitable” cells. Second, patch recording has greatly simplified electrophysiology, especially for small cells. Third, molecular biology has produced primary sequences of channel proteins, making structure-function studies more than just a dream.
KeywordsMarkov Model Relative Permeability Voltage Dependence Charge Movement Exponential Component
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