Bioenergetics pp 451-465 | Cite as

Thirty Years of Mitochondrial Pathophysiology: From Luft’s Disease to Oxygen Toxicity

  • Lars Ernster
  • Chuan-pu Lee


Over the last three decades there has been a growing interest in mitochondrial pathophysiology. Beginning with the first report on a clinical syndrome related to mitochondrial dysfunction, published in 1959 by Ernster, Ikkos and Luft (1) and later commonly referred to as Luffs disease, the number of reports on mitochondrial diseases has been increasing at a progressive rate and is now up in the several hundreds (Fig. 1).


Endurance Training Mitochondrial Disease Mitochondrial Signalling Skeletal Muscle Mitochondrion Oxidase Deficiency 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Lars Ernster
    • 1
  • Chuan-pu Lee
    • 2
  1. 1.Department of Biochemistry, Arrhenius LaboratoriesStockholm UniversityStockholmSweden
  2. 2.Department of BiochemistryWayne State University, School of MedicineDetroitUSA

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