Bioenergetics pp 399-412 | Cite as

Regulation of Activity and Tissue-Specific Expression of Cytochrome C Oxidase Genes under Normal and Pathological Conditions

  • B. Kadenbach
  • U. Büge
  • F.-J. Hüther
  • C. Thiel
  • M. Droste
  • A. Schlerf
  • B. Schneyder
  • L. Kuhn-Nentwig
  • J. Müller-Höcker


Life originated from anaerobic conditions, and also today some unicellular organisms can live without oxygen. But all multicellular organisms require mitochondrial respiration, which is coupled to phosphorylation of ADP to ATP, as an additional and essential source of energy. The rate of cellular respiration varies largely between different cells and tissues and under different endogenous or environmental conditions of an organism. Thus regulation of the rate of respiration represents an essential feature of eucaryotic cell metabolism. The terminal step of the mitochondrial respiratory chain, the formation of water from oxygen, electrons and protons, is catalyzed by cytochrome c oxidase (COX) and involves a large change of the free energy G. Therefore this enzyme represents a bottle-neck or pacemaker of oxidative metabolism. Three mechanisms are known which influence the rate of COX activity: 1) Respiratory control; according to the chemiosmotic hypothesis (1) the activity is controlled by the proton chemical potential across the inner mitochondrial membrane (2). 2) Regulation of activity by substrates (i.e. the concentrations of reduced cytochrome c and oxygen (3)) and allosteric effectors like phosphate, ADP and ATP (see below). 3) Variation of the regulatory response to allosteric effectors by expression of tissue-and developmental-specific isozymes (4–5).


Brown Adipose Tissue Bovine Liver Mitochondrial Myopathy Bovine Heart Paracoccus Denitrificans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • B. Kadenbach
    • 1
  • U. Büge
    • 1
  • F.-J. Hüther
    • 1
  • C. Thiel
    • 1
  • M. Droste
    • 1
  • A. Schlerf
    • 1
  • B. Schneyder
    • 1
  • L. Kuhn-Nentwig
    • 1
  • J. Müller-Höcker
    • 1
  1. 1.Fachbereich ChemiePhilipps-UniversitätMarburgGermany

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