The Effects of Nicotine on Aortic Endothelial Cell Turnover and Ultrastructure

  • Matthew Zimmerman
  • John K. McGeachie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)


Endothelial cell injury is one of the earliest detectable changes in the initiation of arterial intimai hyperplasia and atherosclerosis (Ross and Glomset, 1976; Moore, 1981; Ross, 1986). These early pathological changes are associated with the development of lesions which result in clinical conditions such as myocardial infarction, stroke and peripheral vascular disease. Cigarette smoking has been linked to arterial disease for over 30 years (Surgeon General USA, 1964; 1979) and is a well-recognized risk factor. However the direct relationship between smoking and the pathogenesis of arterial disease has not been precisely defined.


Arterial Disease Gelatin Film Endothelial Cell Density Endothelial Cell Injury Aortic Endothelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Matthew Zimmerman
    • 1
  • John K. McGeachie
    • 2
  1. 1.Queen Elizabeth II Medical CentrePerthWestern Australia
  2. 2.Department of Anatomy and Human BiologyThe University of Western AustraliaWestern Australia

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