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Effects of Cigarette Smoke and Nicotine on Platelets and Experimental Coronary Artery Thrombosis

  • J. D. Folts
  • S. A. Gering
  • S. W. Laibly
  • B. G. Bertha
  • F. C. Bonebrake
  • J. W. Keller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)

Abstract

The first study linking smoking with predicted risk of cardiovascular disease was published in 1958 (1), and this has been confirmed by numerous epidemiologic studies from around the world. The major forms of coronary artery disease and peripheral vascular disease associated with smoking are the result of progressive development of atherosclerosis. Atherosclerotic plaques and fatty streaks can occur early in life as shown in the Korean war autopsy studies in 1953 (2), and confirmed by several other studies (3,4). By some unknown mechanism smoking appears to accelerate the development of the atherosclerotic process.

Keywords

Coronary Artery Platelet Aggregation Arterial Blood Pressure Platelet Activity Platelet Rich Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. D. Folts
    • 1
  • S. A. Gering
    • 1
  • S. W. Laibly
    • 1
  • B. G. Bertha
    • 1
  • F. C. Bonebrake
    • 1
  • J. W. Keller
    • 1
  1. 1.Department of MedicineUniversity of WisconsinMadisonUSA

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