Effect of Nicotine and Carbon Monoxide on Prostacyclin Production by the Rabbit Heart

  • David James Effeney
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 273)


Tobacco smoking is an addictive disorder associated with excessive cardiovascular mortality (1–3). Cigarette smokers have twice the risk of death from coronary artery disease compared with their non-smoking contemporaries. Why cigarettes are addictive is not known with certainty. However, the most likely agent is nicotine (5). Bolus injections of the drug like single puffs of cigarettes result in a rapid rise in the blood concentration, a change in the sensorium and physiologic responses such as increased heart rate, a rise in the blood pressure and peripheral vasconstriction (6,7). Other compounds in this complex aerosol-carbon monoxide, tars, particulate matter, and cyanide-have potentially significantly deleterious effects on the heart and blood vessels as well as the organism as a whole.


Arachidonic Acid Interventricular Septum Rabbit Heart Nicotine Concentration Plasma Nicotine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • David James Effeney
    • 1
  1. 1.Princess Alexandra HospitalUniversity of QueenslandBrisbaneAustralia

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