Cigarette Smoking and Platelet Function: Relation to Nicotine, Carbon Monoxide and Saturated Fat
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 273)
Smoking has been associated with myocardial infarction, independently of its association with atherosclerotic lesions (1). Since coronary thrombosis is the proximate cause of acute myocardial infarction (2) as confirmed recently by the success of thrombolysis to reopen coronary arteries (3), smoking could act directly on the predisposition to thrombosis. Platelet reactivity seems to play a key role in the thrombotic tendency since, in a recent prospective study on 2500 subjects in Wales (5), aspirin significantly reduced acute coronary events (4) and platelet hyperaggregability to ADP was significantly related to the prevalent cases of myocardial infarction. Thus, it is important to determine whether smoking increases platelet reactivity and additionally which smoke components could be involved in this effect. Finally, in the Seven Country Study (6), smoking was less of a risk factor for heart attacks in Southern Europe and Japan than in the USA and northern Europe. Since the consumption of saturated fats was much lower in Japan (3% of calories) and southern Europe (7–10%) than in the USA (18%) and northern Europe (19–22%), the effect of smoking on platelets could be additive to that of saturated fats which are known to markedly increase their reactivity (7). Results of our studies on the effect of smoking, smoke components and saturated fats on platelet function tests are briefly reviewed hereafter.
KeywordsCigarette Smoking Platelet Aggregation Platelet Function Platelet Rich Plasma Coronary Thrombosis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
A.J. Hartz, P.N. Barboriak, A.J. Anderson, R.B. Hoffmann, and JJ. Barboriak. Smoking, coronary artery occlusion and nonfatal myocardial infarction, J.A.M.A.
246:851 (1981).PubMedCrossRefGoogle Scholar
M.A. De Wood, J. Spores, R. Notske. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction, N. Engl. J. Med.
303:897 (1980).CrossRefGoogle Scholar
AIMS TRIAL study group. Effect of intravenous APSAC on mortality after acute myocardial infarction: preliminary report of a placebo-controlled clinical trial, Lancet
, 1:545 (1988).Google Scholar
V. Fuster, M. Cohen, J. Halpern. Aspirin in the prevention of coronary disease, N. Engl. J. Med.
321:183 (1989).PubMedCrossRefGoogle Scholar
P.C. Elwood, S. Renaud, D.S. Sharp, A.O. Beswick, J.R. O’Brien and J.W.G. Yarnell. Ischaemic heart disease and platelet aggregation: the Caerphilly collaborative heart disease study (Submitted for publication).Google Scholar
A. Keys, Seven Countries. A multivariate analysis of death and coronary heart disease. Harvard University Press, Cambridge, MA, USA (1980).Google Scholar
S. Renaud, R. Morazain, F. Godsey, E. Dumont, C. Thevenon, J.L. Martin, F. Mendy. Nutrients, platelet function and composition in nine groups of French and British farmers, Atherosclerosis
60:37 (1986).PubMedCrossRefGoogle Scholar
P.H. Levine. An acute effect of cigarette smoking on platelet function, Circulation
48:619 (1973).PubMedGoogle Scholar
W. Siess, R. Lorenz, P. Roth, P.C. Weber, Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion, Circulation
66:44 (1983).CrossRefGoogle Scholar
S. Renaud, D. Blache, E. Dumont, C. Thevenon, and T. Wissendanger. Platelet function after cigarette smoking in relation to nicotine and carbon monoxide. Clin. Pharmacol. Ther.
36:389 (1984).PubMedCrossRefGoogle Scholar
S. Renaud, E. Dumont, F. Baudier, E. Ortchanian, and I.S. Symington. Effect of smoking and dietary saturated fats on platelet functions in Scottish farmers, Cardiovasc. Res
. 19:155 (1985).PubMedCrossRefGoogle Scholar
S. Renaud, and F. Lecompte. Hypercoagulability induced by hyperlipemia in rat, rabbit and man. Role of platelet factor 3, Circ. Res.
27:1003 (1979).Google Scholar
M.A.H. Russell, M. Jarvis, R. Iyer, and C. Feyerabend. Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers, Br. Med. J.
1:972 (1980).CrossRefGoogle Scholar
D. Blache, C. Thevenon, M. Ciavatti, and S. Renaud. A sensitive method for the routine determination of plasma nicotine by flame ionization gas-liquid chromatography, Analyt. Biochem.
143:316 (1984).PubMedCrossRefGoogle Scholar
M.E. McNabb, R.V. Ebert, and K. McCusker. Plasma nicotine levels produced by chewing nicotine gum, J.A.M.A.
248:865 (1982).PubMedCrossRefGoogle Scholar
K. Brinson. Effect of nicotine on human blood platelet aggregation. Atherosclerosis
20:127 (1975).Google Scholar
S.R. Saba, and R.G. Mason. Some effects of nicotine on platelets, Thromb. Res.
S. Renaud, R. Morazain, F. Godsey, E. Dumont, I.S. Symington, E.M. Gillanders, and J.R. O’Brien. Platelet functions in relation to diet and serum lipids in British farmers, Brit. Heart J.
46:562 (1981).PubMedCrossRefGoogle Scholar
R. Doll, R. Peto. Mortality in relation to smoking: 20 years’ observations on male British doctors, Brit. Med. J.
2:1526 (1976).CrossRefGoogle Scholar
T. Gordon, N.B. Kannel, D. McGee, and T.R. Dawber. Death and coronary attacks in men after giving up cigarette smoking, Lancet
2: 1345 (1974).PubMedCrossRefGoogle Scholar
W.C. Willett, C.H. Hennekens, C. Bain, B. Rosner and F.E. Speizer. Cigarette smoking and non-fatal myocardial infarction in women, Amer. J. Epidemiol.
113:575 (1981).Google Scholar
J.T. Doyle, T.R. Dawber, W.B. Kannel, S.H. Kinch, and H.A. Kahn. The relationship of cigarette smoking to coronary heart disease, J.A.M.A.
190:886 (1964).PubMedCrossRefGoogle Scholar
G. Grignani, G. Gamba and E. Ascari. Cigarette-smoking effect on platelet function, Thromb. Haemost.
37:442 (1977).Google Scholar
I. Hjermann, K. Velve Byre, I. Holme, and P. Leren. Effect of diet and smoking intervention on the incidence of coronary heart disease, Lancet
2:1303 (1981).PubMedCrossRefGoogle Scholar
© Plenum Press, New York 1990