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Effect of L-Carnitine Upon Ammonia Tolerance Test in Cirrhotic Patients

  • J. A. del Olmo
  • M. Castillo
  • J. M. Rodrigo
  • L. Aparisi
  • M. A. Serra
  • A. Wassel
  • M. Bixquert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 272)

Summary

In a group of liver cirrhosis (LC) patients subjected to a rectal ammonium overload test, the effect of L-carnitine on ammoniemia and on the type A numerical connection and star clock psychomotor tests has been evaluated.

On comparing 40 LC patients given L-carnitine with 40 control cirrhotics given a placebo, no significant differences were observed in ammonium levels after performing the overload test in both groups.

However, on studying the patients with the greatest liver involvement, those given L-carnitine showed smaller elevations in ammoniemia and better responses to the psychometric tests than those receiving the placebo.

The results obtained emphasize the need to continue testing the effect of L-carnitine using either similar tests or carrying out long-term evaluations to determine its protective effect in the appearance of hepatic encephalopathy, perhaps even including its evaluation in the treatment of established encephalopathy.

Keywords

Portal Hypertension Hepatic Encephalopathy Primary Biliary Cirrhosis Psychometric Test Liver Cirrhosis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. A. del Olmo
    • 1
  • M. Castillo
    • 1
  • J. M. Rodrigo
    • 1
  • L. Aparisi
    • 1
  • M. A. Serra
    • 1
  • A. Wassel
    • 1
  • M. Bixquert
    • 1
  1. 1.Servicio de Aparato DigestivoHospital Clínico UniversitarioValenciaSpain

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