Epigenetic Factors Influencing the Morphogenesis of Primary Neural Cell Cultures and the Concomitant Effects on Establishing JHMV Infections
The murine Coronavirus, JHM, produces a spectrum of disease in the postnatal rat ranging from an acute encephalomyelitis to a delayed onset disease clinicopathologically characterized by limb paresis progressing to paralysis, with associated foci of demyelination within white matter tracts of the rhombencephalon and spinal cord. The type of disease predominating in intracerebrally inoculated rat pups was found by previous work in our laboratory to be a function of the following host determinants: strain of animal challenged, age at which the animal was inoculated and the host–s immunologic status (1,2,3). Other parameters such as the phenotype of the virion–s major envelope glycoprotein, E2 (4,5,6) and the length of the latent period or time elapsing between inoculation and development of disease (1), are examples of other determinants involved in the pathogenic outcome of virus challenge in vivo.
KeywordsDemyelinating Disease Intracellular cAMP Level Multiple Sclerosis Society Oligodendrocyte Lineage Delay Onset Disease
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