Difference in Response of Susceptible Mouse Strains to a Small Plaque Mutant (JHM-CC) of Mouse Coronavirus
The JHM-CC virus is a small plaque mutant isolated from the DBT cell culture persistently infected with JHM (1), the most neurotropic strain of mouse Coronavirus (2). This JHM-CC virus had been shown to induce severe vacuolar degeneration in the brainstem and spinal cord of the infected ICR mice (1,3). Since the strain difference of mice in their susceptibility to various strains of mouse coronaviruses including parental JHM virus has been documented (4,5), we compared the kinetics of virus production and neuropathological changes after intracerebral inoculation of the JHM-CC virus in three strains of mice.
KeywordsSpinal Cord Choroid Plexus C57BL Mouse Mouse Hepatitis Virus Intracerebral Inoculation
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