Difference in Response of Susceptible Mouse Strains to a Small Plaque Mutant (JHM-CC) of Mouse Coronavirus

  • Norio Hirano
  • Tetsuro Tsukamoto
  • Satoshi Haga
  • Yuzo Iwasaki
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


The JHM-CC virus is a small plaque mutant isolated from the DBT cell culture persistently infected with JHM (1), the most neurotropic strain of mouse Coronavirus (2). This JHM-CC virus had been shown to induce severe vacuolar degeneration in the brainstem and spinal cord of the infected ICR mice (1,3). Since the strain difference of mice in their susceptibility to various strains of mouse coronaviruses including parental JHM virus has been documented (4,5), we compared the kinetics of virus production and neuropathological changes after intracerebral inoculation of the JHM-CC virus in three strains of mice.


Spinal Cord Choroid Plexus C57BL Mouse Mouse Hepatitis Virus Intracerebral Inoculation 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Norio Hirano
    • 1
  • Tetsuro Tsukamoto
    • 2
  • Satoshi Haga
    • 1
  • Yuzo Iwasaki
    • 3
  1. 1.Department of Veterinary MicrobiologyIwate UniversityMoriokaJapan
  2. 2.Department of NeurologyTohoku University School of MedicineSendaiJapan
  3. 3.Department of Neurological ScienceTohoku University School of MedicineSendaiJapan

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