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Vacuolar Degeneration Induced by JHM-CC Virus in the CNS of Cyclophosphamide-Treated Mice

  • Yuzo Iwasaki
  • Norio Hirano
  • Tetsuro Tsukamoto
  • Satoru Haga
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)

Abstract

The infection with JHM-CC virus (1), a small plaque mutant of neuro-virulent JHM virus, is non-fatal in immunocompetent mice but constantly induces vacuolar degeneration in the brain and spinal cord (2). To elucidate the role of host immune response in pathogenesis of JHM-CC induced vacuolar degeneration in the central nervous system (CNS), the kinetics of virus growth and the temporal sequence of viral antigen distribution were correlated with histopathological changes in cyclophosphamide-treated adult ICR mice.

Keywords

Olfactory Bulb Viral Antigen Mitral Cell Central Nervous System Tissue Immunocompetent Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Yuzo Iwasaki
    • 1
  • Norio Hirano
    • 2
  • Tetsuro Tsukamoto
    • 3
  • Satoru Haga
    • 2
  1. 1.Department of Neurological SciencesTohoku University School of MedicineSendaiJapan
  2. 2.Department of Veterinary MicrobiologyIwate UniversityMoriokaJapan
  3. 3.Department of NeurologyFukushima Medical CollegeFukushimaJapan

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