Vacuolar Degeneration Induced by JHM-CC Virus in the CNS of Cyclophosphamide-Treated Mice
The infection with JHM-CC virus (1), a small plaque mutant of neuro-virulent JHM virus, is non-fatal in immunocompetent mice but constantly induces vacuolar degeneration in the brain and spinal cord (2). To elucidate the role of host immune response in pathogenesis of JHM-CC induced vacuolar degeneration in the central nervous system (CNS), the kinetics of virus growth and the temporal sequence of viral antigen distribution were correlated with histopathological changes in cyclophosphamide-treated adult ICR mice.
KeywordsOlfactory Bulb Viral Antigen Mitral Cell Central Nervous System Tissue Immunocompetent Mouse
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