Mouse Hepatitis Virus A59 Increases Steady-State Levels of mRNAs Encoding Major Histocompatibility Complex Antigens

  • James L. Gombold
  • Susan R. Weiss
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


The murine hepatitis viruses (MHV) have been widely studied as models of human neurologic infections. MHV strains A59 and JHM cause an acute necrotizing encephalitis in mice when inoculated intracerebrally. Studies using low doses of virus, attenuated virus strains, or temperature-sensitive mutants have shown that animals surviving the acute infection develop a chronic disease characterized by inflammatory demyelination of neurons in the central nervous system (Haspel et al., 1978; Knobler et al., 1982; Lavi et al., 1986; Koolen et al., 1987).


Mouse Hepatitis Virus Major Histocompatibility Complex Antigen Murine Hepatitis Virus Guanidinium Isothiocyanate Primary Glial Cell 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • James L. Gombold
    • 1
  • Susan R. Weiss
    • 1
  1. 1.Department of MicrobiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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