Mechanism of Protective Effect of Prostaglandin E in Murine Hepatitis Virus Strain 3 Infection: Effects on Macrophage Production of Tumour Necrosis Factor, Procoagulant Activity and Leukotriene B4

  • S. Sinclair
  • M. Abecassis
  • P. Y. Wong
  • A. Romaschin
  • L. S. Fung
  • G. Levy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Murine hepatitis virus strain 3 (MHV-3) produces a strain dependent spectrum of liver disease. Mice of the A strain are fully resistant whereas Balb/cJ mice die of fulminant hepatic failure (1) . The susceptibility of inbred mice to MHV-3, is dependent on host factors which are under strict genetic control. Differences in viral replication both invivo and in-vitro do not appear to account for strain-dependent differences in resistance to MHV-3 and it has been suggested that variation in susceptibility/resistance of inbred mice reflects defects in the host–s immune response (2). Experimental ablation of the immune cell populations by X irradiation (3) , antilymphocyte serum (4) , or infection with frog virus-3 (5) renders resistant A/J mice susceptible. Furthermore, reconstitution of susceptible neonatal A/J mice with adult immune cells requires both T lymphocytes and an adherent cell population (6) . More recently, it has been demonstrated that clearance of virus from the central nervous system is dependent upon the presence of both CD4+ and CD8+ cells that recognize viral antigens in the context of H-2D gene products (7).


Peritoneal Macrophage Procoagulant Activity Mouse Hepatitis Virus 17CL1 Cell Murine Hepatitis Virus 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • S. Sinclair
    • 1
  • M. Abecassis
    • 1
  • P. Y. Wong
    • 2
  • A. Romaschin
    • 2
  • L. S. Fung
    • 1
  • G. Levy
    • 1
  1. 1.Department of MedicineUniversity of TorontoTorontoCanada
  2. 2.Department of BiochemistryUniversity of TorontoTorontoCanada

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