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Murine Coronavirus Temperature Sensitive Mutants

  • Ralph S. Baric
  • Mary C. Schaad
  • Theodore Wei
  • Kaisong Fu
  • Karen Lum
  • Carol Shieh
  • Stephen A. Stohlman
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)

Abstract

Mouse hepatitis virus (MHV), a member of the Coronaviridae, contains a single-stranded, nonsegmented, plus-polarity RNA of 8.0 × 106 daltons molecular weight1 . The ~32KB genomic RNA is organized into seven genetic regions each encoding one or more viral proteins 1,2. In the virion, the RNA is enclosed in a helical nucleocapsid structure constructed from multiple copies of a 50-60KD phosphorylated nucleocapsid protein(N). The viral envelope is derived from modified host internal membranes and contains two virus-encoded glycoproteins designated M (gp23) and S(gpl80/90) 1,3.

Keywords

Complementation Group mRNA Synthesis Restrictive Temperature Mouse Hepatitis Virus Prewarmed Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Ralph S. Baric
    • 1
  • Mary C. Schaad
    • 1
  • Theodore Wei
    • 2
  • Kaisong Fu
    • 1
  • Karen Lum
    • 1
  • Carol Shieh
    • 1
  • Stephen A. Stohlman
    • 2
  1. 1.Department of Parasitology and Laboratory Practice School of Public HealthUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Department of Neurology and MicrobiologyUniversity of Southern California School of MedicineLos AngelesUSA

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