The Nucleocapsid Protein of IBV Comprises Immunodominant Determinants Recognized by T-Cells
Infectious bronchitis virus (IBV), the type species of the coronaviridae, is the causative agent of an acute respiratory disease in chickens. The positive stranded RNA genome of IBV encodes three major structural proteins: two N-glycosylated envelope proteins, El and E2, and a nonglycosylated nucleocapsid protein (N). The E2 protein, or spike protein, consists of two or more copies of structurally unrelated subunits (S1 and S2) with relative molecular masses of 90 and 84 kd, respectively. The El protein, or matrix protein, occurs in several forms (27 to 36 kd). The phosphorylated basic nucleoprotein (56 kd) is closely associated with the viral RNA.
KeywordsRabies Virus Infectious Bronchitis Virus Nucleocapsid Protein Expression Product Mouse Hepatitis Virus
Unable to display preview. Download preview PDF.
- 7.H. G. M. Niesters, J. A. Lenstra, W. J. M. Spaan, A. J. Zijderveld, N. M. Bleumink Pluym, F. Hong, G. J. M. van Scharrenburg, M. C. Horzinek and B. A. M. van der Zeijst. 1986. The peplomer protein sequence of the M41 strain of Coronavirus IBV and its comparison with Beaudette strains. Virus Res. 5, 253–263.PubMedCrossRefGoogle Scholar
- 11.R. H. Smith, and B. Ziola. 1986. Cyclophosphamide and dimethyl dioctadecyl ammonium bromide immuno-potentiate the delayed type hypersensitivity response to inactivated enveloped viruses. Immunol. 58, 245–250.Google Scholar
- 14.W. van Eden, A. Noordzij, E. J. Hensen, R. van der Zee, J. D. A van Embden and R. Meloen. 1989. A modified method for the rapid identification and characterization of T-cell epitopes in protein antigens. Modern approaches to new vaccines including prevention of AIDS. Cold Spring Harbor Laboratory, Cold Spring Harbor 33–36.Google Scholar