The Nucleocapsid Protein of IBV Comprises Immunodominant Determinants Recognized by T-Cells

  • Annemieke M. H. Boots
  • Johannes G. Kusters
  • Bernard A. M. van der Zeijst
  • Evert J. Hensen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Infectious bronchitis virus (IBV), the type species of the coronaviridae, is the causative agent of an acute respiratory disease in chickens. The positive stranded RNA genome of IBV encodes three major structural proteins: two N-glycosylated envelope proteins, El and E2, and a nonglycosylated nucleocapsid protein (N). The E2 protein, or spike protein, consists of two or more copies of structurally unrelated subunits (S1 and S2) with relative molecular masses of 90 and 84 kd, respectively. The El protein, or matrix protein, occurs in several forms (27 to 36 kd). The phosphorylated basic nucleoprotein (56 kd) is closely associated with the viral RNA.


Rabies Virus Infectious Bronchitis Virus Nucleocapsid Protein Expression Product Mouse Hepatitis Virus 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Annemieke M. H. Boots
    • 1
  • Johannes G. Kusters
    • 1
  • Bernard A. M. van der Zeijst
    • 1
  • Evert J. Hensen
    • 1
  1. 1.Institute of Infectious Diseases and Immunology, Fac. of Vet. MedicineUniversity of UtrechtUtrechtThe Netherlands

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