Expression of MHV-A59 M Glycoprotein: Effects of Deletions on Membrane Integration and Intracellular Transport
The M protein of coronaviruses is an integral membrane protein, the general properties of which have been described elsewhere in this volume. The protein is ascribed a pivotal role in the budding process of these viruses. Its restriction to internal membranes suggests it to be a major factor in determining the intracellular site of virion assembly. In addition, M is thought to effect budding through the interaction of its cytoplasmic tail with the nucleocapsid.
KeywordsMutant Protein Infectious Bronchitis Virus Recombinant Vaccinia Virus Feline Infectious Peritonitis Indirect Immunofluorescence Microscopy
Unable to display preview. Download preview PDF.