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Expression of MHV-A59 M Glycoprotein: Effects of Deletions on Membrane Integration and Intracellular Transport

  • P. J. M. Rottier
  • J. Krijnse Locker
  • M. C. Horzinek
  • W. J. M. Spaan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)

Abstract

The M protein of coronaviruses is an integral membrane protein, the general properties of which have been described elsewhere in this volume. The protein is ascribed a pivotal role in the budding process of these viruses. Its restriction to internal membranes suggests it to be a major factor in determining the intracellular site of virion assembly. In addition, M is thought to effect budding through the interaction of its cytoplasmic tail with the nucleocapsid.

Keywords

Mutant Protein Infectious Bronchitis Virus Recombinant Vaccinia Virus Feline Infectious Peritonitis Indirect Immunofluorescence Microscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • P. J. M. Rottier
    • 1
  • J. Krijnse Locker
    • 1
  • M. C. Horzinek
    • 1
  • W. J. M. Spaan
    • 1
  1. 1.Veterinary Faculty, Department of Infectious Diseases and Immunology, Institute of VirologyState UniversityUtrechtThe Netherlands

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