Expression of the Porcine Transmissible Gastroenteritis Coronavirus M Protein

  • Brenda G. Hogue
  • Debi P. Nayak
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Cloned cDNA encoding the M protein of the porcine transmissible gastroenteritis Coronavirus (TGEV) was introduced into a vaccinia virus to examine the function of the amino-terminal signal peptide. The M protein expressed by the recombinant virus was targeted to the Golgi region of infected cells, as is the M protein in cells infected with TGEV. The protein appeared not to undergo processing other than glycosylation. However, the vaccinia-expressed M protein was slightly larger than the protein found in TGEV-infected cells, suggesting that a difference in modification exists between the proteins.


Recombinant Virus Infectious Bronchitis Virus Recombinant Vaccinia Virus cDNA Copy Mouse Hepatitis Virus 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Brenda G. Hogue
    • 1
  • Debi P. Nayak
    • 1
  1. 1.Department of Microbiology and ImmunologyUCLA School of MedicineLos AngelesUSA

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