The Haemagglutinin of Bovine Coronavirus Exhibits Significant Similarity to the Haemagglutinin of Type C Influenza Virus
Coronaviruses are large enveloped RNA viruses containing a single-stranded genome complexed with a phosphorylated nucleocapsid protein which is surrounded by an envelope derived from intracellular membranes. The envelope contains two or three species of glycoproteins. The largest, E2 or S, is cleaved to S1 and S2 subunits and forms the large club-shaped peplomers on the surface of the virion which gives the virus its characteristic appearance. The El glycoprotein is believed to be responsible for determining the intracellular site of viral morphogenesis. A smaller group of coronaviruses contain a third membrane glycoprotein (Hogue and Brian, 1986, King et al., 1985, Pocock and Garwes, 1977), E3 or H, which, in the case of bovine Coronavirus , exhibits haemagglutinating and acetylesterase activities.
KeywordsInfluenza Virus Haemagglutination Inhibit Murine Hepatitis Virus Bovine Coronavirus National Biomedical Research Foundation
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