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Biohalogenation

  • Kenneth L. Kirk
Part of the Biochemistry of the Elements book series (BOTE, volume 9A+B)

Abstract

A vast number of halogenated compounds are present in the biosphere. While most of these have resulted from the work of synthetic chemists, a large number are naturally occurring—products of nature’s halogenation processes. The majority of these naturally occurring halogenated compounds are produced by haloperoxidases, a group of enzymes widely distributed in nature that are capable of halogenating a broad spectrum of organic substrates. A comprehensive review of recent research involved with isolation, identification, and biological evaluation of naturally occurring halogenated compounds, now an active area of natural products chemistry, is beyond the scope of this chapter. Recent reviews are available and will be cited (e.g., Neidleman and Geigert, 1986, 1987). While examples of halometabolites produced by various species will be given—particularly compounds that have useful medical applications—the emphasis in this chapter will be placed on the biochemical processes that produce the halometabolites. Thus, the mechanism of halogenation by haloperoxidases will be reviewed, and specific examples of haloperoxidases will be given, including recently identified vanadium-containing nonheme haloperoxidases.

Keywords

Marine Organism Thyroid Peroxidase Marine Natural Product Halogenating Species Hypohalous Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kenneth L. Kirk
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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