Biochemistry of Inorganic Iodide
As a constituent of thyroid hormones, iodine—the heaviest element metabolized in biological materials—plays a unique and essential role in mammalian biochemistry, and, accordingly, the vast majority of research dealing with inorganic iodide (I−) has been related to this role. The biochemistry of thyroid hormones is reviewed in Chapter 6, which includes an overview of the process by which I− is incorporated into thyroid hormones through bioiodination. In this chapter, the more general aspects of the biochemistry of I− will be considered, including occurrence, uptake, biodistribution, and metabolism of I−. Transport mechanisms, in particular, the mechanisms by which the thyroid gland concentrates I−, will be reviewed as will the interaction of I− with enzymes.
KeywordsThyroid Hormone Thyroid Gland Carbonic Anhydrase Apical Membrane Thyroid Cell
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