Biochemistry of Inorganic Iodide

  • Kenneth L. Kirk
Part of the Biochemistry of the Elements book series (BOTE, volume 9A+B)


As a constituent of thyroid hormones, iodine—the heaviest element metabolized in biological materials—plays a unique and essential role in mammalian biochemistry, and, accordingly, the vast majority of research dealing with inorganic iodide (I) has been related to this role. The biochemistry of thyroid hormones is reviewed in Chapter 6, which includes an overview of the process by which I is incorporated into thyroid hormones through bioiodination. In this chapter, the more general aspects of the biochemistry of I will be considered, including occurrence, uptake, biodistribution, and metabolism of I. Transport mechanisms, in particular, the mechanisms by which the thyroid gland concentrates I, will be reviewed as will the interaction of I with enzymes.


Thyroid Hormone Thyroid Gland Carbonic Anhydrase Apical Membrane Thyroid Cell 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kenneth L. Kirk
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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