An Influenza Epidemic and the Seasonality of Schizophrenic Births

  • E. Fuller Torrey
  • Ann E. Bowler
  • Robert Rawlings


The occurrence of psychosis following epidemics of influenza was noted as early as 1846 (Rorie, 1901). In the wake of the 1889–1890 influenza pandemic, Althaus (1893) reviewed 34 articles on “psychoses following influenza” which had been published in the preceding 3 years. The deadly influenza pandemic of 1918–1919 was also followed by a spate of articles, including Menninger’s (1926) review of 200 postinfluenzal psychoses admitted to a single hospital of which “one-third looked like and were labeled dementia praecox.” More recently the influenza pandemic of 1957, caused by an influenza A viral strain which was especially neurotropic, produced reports of manic and schizophrenic-like psychoses from at least six countries (Bental, 1958; Lloyd Still, 1958; Prokop, 1958; Soeiro, 1958; Loo et al., 1957; Chistovich, 1959).


Influenza Virus Trigeminal Ganglion Influenza Pandemic Herpes Simplex Encephalitis Total Birth 


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  1. Althaus, J., 1893, On psychoses after influenza, J. Ment. Sci. 39: 163–176.Google Scholar
  2. Bental, E., 1958, Acute psychosis due to encephalitis following Asian influenza, Lancet 2:18–20. Boyd, J. H., Pulver, A. E., and Stewart, W, 1986, Season of birth: Schizophrenia and bipolar disorder, Schiz. Bull. 12: 173–186.Google Scholar
  3. Bradbury, T. N., and Miller, G. A., 1985, Season of birth in schizophrenia: A review of evidence, methodology, and etiology, Psychol. Bull. 98: 569–594.PubMedCrossRefGoogle Scholar
  4. Chistovich, A. S., 1959, The value of microbiological testing in the diagnosis and therapy of mental diseases, Nauch. Konferen. Posvyashch. 20: 113–119.Google Scholar
  5. Colter, N., Bartal, S., Crow, T J., Johnstone, E. C., Brown, R., and Bruton, C., 1987, White matter reduction in the parahippocampal gyrus of patients with schizophrenia [letter], Arch. Gen. Psychiatry 44: 1023.PubMedCrossRefGoogle Scholar
  6. Davis, L. E., and Johnson, R. T, 1979, An explanation for the localization of herpes simplex encephalitis, Ann. Neurol. 5: 2–5.PubMedCrossRefGoogle Scholar
  7. Langmuir, A. D., 1961, Epidemiology of Asian influenza, Am. Rev. Resp. Dis. 83: 2–10.PubMedGoogle Scholar
  8. Lloyd Still, R. M., 1958, Psychosis following Asian influenza in Barbados, Lancet 2: 20–22.CrossRefGoogle Scholar
  9. Loo, M. P., Eloy, G., and Duflot, M. J.-P., 1957, Infections et psychoses, Ann. Med. Psychol. 115: 737–744.Google Scholar
  10. Mednick, S. A., Machon, R. A., Huttunen, M. O., and Bonett, D., 1988, Adult schizophrenia following prenatal exposure to an influenza epidemic, Arch. Gen. Psychiatry 45: 189–192.PubMedCrossRefGoogle Scholar
  11. Menninger, K. A., 1926, Influenza and insanity, Am. J. Psychiatry 5: 469–529.Google Scholar
  12. Morbidity and Mortality Weekly Reports (MMWR), 1957, National Office of Vital Statistics, U.S. Public Health Service, Washington, D. C.Google Scholar
  13. Prokop, H., 1958, Psychosen im rahmen der grippeep: demie 1957/58, Arch. Psychiatr. (Berlin) 197: 484–500.Google Scholar
  14. Ravenholt, R. T., and Foege, W. H., 1982, 1918 influenza, encephalitis lethargica, Parkinsonism, Lancet 2: 860–864.Google Scholar
  15. Rorie, G. A., 1901, Post-influenzal insanity in the Cumberland and Westmoreland asylum, with statistics of sixty-eight cases, J. Ment. Sci. 47: 317–326.Google Scholar
  16. Soeiro, L. N., 1958, Pricoses gripais, J. Med. (Porto) 37: 757–759.Google Scholar
  17. Torrey, E. F.,1987, Viruses as the possible cause of schizophrenic birth seasonality, in: Seasonal Effects on Reproduction, Infection and Psychoses (T. Miura, ed.), SPB Academic Publishing, The Hague.Google Scholar
  18. Torrey, E. F., Torrey, B. B., and Peterson, M. R., 1977, Seasonality of schizophrenic births in the United States, Arch. Gen. Psychiatry 34: 1065–1070.CrossRefGoogle Scholar
  19. Torrey, E. F, Rawlings, R., and Waldman, I. N., 1988, Schizophrenic births and viral diseases in two states, Schiz. Res. 1: 73–77.CrossRefGoogle Scholar
  20. Watson, C. G., Kulcala, T., Tilleskjor, C., and Jacobs, L., 1984, Schizophrenic birth seasonality in relation to the incidence of infectious diseases and temperature extremes, Arch. Gen. Psychiatry 41: 85–90.PubMedCrossRefGoogle Scholar
  21. Weiner, L. P., and Fleming, J. 0., 1984, Viral infections of the nervous system, J. Neurosurg. 61: 207–224.PubMedCrossRefGoogle Scholar
  22. Wright, P. F., Thompson, J., and Karzon, D. T.,1980, Differing virulence of H, N, and H3N2 influenza strains, Am. J. Epidemiol. 112: 814–819.Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • E. Fuller Torrey
    • 1
  • Ann E. Bowler
    • 1
  • Robert Rawlings
    • 2
  1. 1.Twin Studies Unit, NIMH Neurosciences CenterSt. Elizabeths HospitalUSA
  2. 2.Division of Biometry and EpidemiologyNational Institute on Alcohol Abuse and AlcoholismRockvilleUSA

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