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Genetic Sequences of Influenza Virus in Children with Congenital CNS Pathology

  • Y. Y. Tentsov
  • V. A. Zuev
  • A. M. Shevchenko
  • A. A. Rzhaninova
  • N. B. Nefedova
  • N. G. Ignatova

Abstract

Early experiments demonstrated that as a result of intranasal inoculation of pregnant mice with influenza A virus, individual offspring could be found 3 weeks after birth with signs of a slowly running infectious process manifested as progressive retardation in weight and body size, and disorders in movement coordination and gait. Such a slow influenza infection in animals is characterized by marked immune deficiency, long-term influenza virus persistence, and progressive degenerative changes in different organs and tissues, among them the brain and spinal cord and the neuroendocrine system. The disease was invariably fatal within 2–3 months (Zuev et al., 1983; Zuev, 1988).

Keywords

Sodium Dodecyl Sulfate Influenza Virus Influenza Infection Genetic Sequence Subacute Sclerosing Panencephalitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Y. Y. Tentsov
    • 1
  • V. A. Zuev
    • 2
  • A. M. Shevchenko
    • 3
  • A. A. Rzhaninova
    • 1
  • N. B. Nefedova
    • 2
  • N. G. Ignatova
    • 2
  1. 1.D. I. Ivanovsky Institute of VirologyUSSR Academy of Medical SciencesMoscowUSSR
  2. 2.N. F. Gamaleya Institute of Epidemiology and MicrobiologyUSSR Academy of Medical SciencesMoscowUSSR
  3. 3.Childhood NeuropathologyBielorussian State Institute for Advanced Medical TrainingMinskUSSR

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