A Virus-Associated Immunopathological Theory of Schizophrenia

  • Royce W. WaltripII
  • Donald R. Carrigan
  • Robert W. Buchanan
  • William T. CarpenterJr.


Schizophrenia is a clinical syndrome which is increasingly considered to be a neurological disease with behavioral symptoms that primarily manifest as dysfunction of frontal and limbic brain areas. Hypotheses of the etiology or etiologies of schizophrenia have tended to be limited to intrinsic central nervous system (CNS) processes, such as neurotransmitter dysregulation or neuroanatomical models. These models have a correspondingly limited predictive validity. An alternate and potentially more useful perspective of the disease would be one that takes into account its pleomorphic nature. Schizophrenia has a broad spectrum of associated findings suggesting involvement of developmental processes and a pathophysiology that may be systemic in nature. Viral hypotheses have been one way that the issue of pleomorphism has been addressed.


Amyotrophic Lateral Sclerosis Schizophrenic Patient Acquire Immune Deficiency Syndrome Measle Virus Viral Reactivation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Royce W. WaltripII
    • 1
  • Donald R. Carrigan
    • 2
  • Robert W. Buchanan
    • 1
  • William T. CarpenterJr.
    • 1
  1. 1.Maryland Psychiatric Research Center, Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of PathologyMedical College of WisconsinMilwaukeeUSA

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