The Effect of Cold or Isolation Stress on Neuroinvasiveness and Neurovirulence of an Avirulent Variant of West Nile Virus (WN-25)

  • D. Ben-Nathan
  • S. Lustig
  • G. Feuerstein


Stress has been defined by Selye (1950, 1957) as a nonspecific response to internal and external stimuli that induces hormonal changes which lead to depression of the immune system. Since stress alters the chemical balance of the body, it probably influences the development of diseases through its effect on the immune system. In order to understand the influence of physical or nonphysical stress on the susceptibility of mice to viral infections, we used avirulent West Nile virus.


Cold Stress West Nile Virus Virus Titer Vero Cell Virus Level 
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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • D. Ben-Nathan
    • 1
  • S. Lustig
    • 1
  • G. Feuerstein
    • 2
  1. 1.Department of VirologyIsrael Institute for Biological ResearchNess-ZionaIsrael
  2. 2.Department of NeurologyUSUHSBethesdaUSA

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